From Harrisburg:

Take I-81 or US-22 east to I-78. US-22 joins I-78. Take I-78/US-22 east. When I-78 and US-22 divide about 7 miles west of Allentown, stay on US-22. Exit at PA-145 north - MacArthur Road.

From Juncture of US-22 and PA-145 North - MacArthur Road:

Take PA-145 north 4-1/2 miles. Turn right onto PA-329 east, and go 1-1/2 miles across the Lehigh River into Northampton to the first traffic light. A PNC Bank and Gulf Station are located at this corner. Turn left onto Main Street. At the traffic light turn left onto Cherryville Road and continue for 3 miles. Mary Immaculate Center is on right.